Friday, December 28, 2012

Survey finds increase in e-reading, drop in paper

2 hrs.

The tastes of the reading public are turning digital.

A Pew Internet Research Center survey released Thursday found that the percentage of Americans aged 16 and older who read an e-book grew from 16 percent in 2011 to 23 percent this year. Readers of traditional books dropped from 72 percent to 67 percent. Overall, those reading books of any kind dropped from 78 percent to 75 percent, a shift Pew called statistically insignificant.

Those owning an e-book device or tablet jumped from 18 percent to 33 percent, with much of that increase coming from last year's holiday season, when millions received Kindles, Nooks and other e-readers as gifts.

Awareness that libraries offer digital texts grew from 24 percent to 31 percent.

The telephone survey of 2,252 people aged 16 and older was conducted from Oct. 15 to Nov. 10. It has a sampling error margin of plus or minus 2.3 percentage points.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.nbcnews.com/technology/technolog/survey-finds-increase-e-reading-drop-paper-1C7661434

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Thursday, December 27, 2012

New insight into cell development and cancer

Dec. 27, 2012 ? Long-standing research efforts have been focused on understanding how stem cells, cells capable of transforming into any type of cell in the body, are capable of being programmed down a defined path to contribute to the development of a specific organ like a heart, lung, or kidney. Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell.

The study, published December 27, 2012 by the journal Molecular Cell, implicates a unique class of proteins called polycomb-like proteins, or PCL's, as bridging molecules between the "on" and "off" state of a gene. While all of these specialized types of cells share the same genetic information encoded in our DNA, it is becoming increasingly clear that information outside the genome, referred to as epigenetics, plays a central role in orchestrating the reprogramming of a stem cell down a defined path.

Although it is understood that epigenetics is responsible for turning genes "on" and "off" at defined times during cellular development, the precise mechanisms controlling this delicate process are less well understood.

"This finding has important implications for both stem cell biology and cancer development, as the same regulatory circuits controlled by PCL's in stem cells are often misregulated in tumors," said Dr. Greg Wang, senior author of the study and Assistant Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center.

The study, led by postdoctoral research fellows Drs. Ling Cai and Rui Lu in the Wang lab, and Dr. Scott Rothbart, a Lineberger postdoctoral fellow in the lab of Dr. Brian Strahl, Associate Professor of Biochemistry and Biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center, identified that PCL's interact with an epigenetic signal associated with genes that are turned on to recruit a group of proteins called the PRC2 complex which then turn genes off.

"In stem cells, the PRC2 complex turns genes off that would otherwise promote reprogramming into specialized cells of organs like the heart or lungs," said Wang.

In addition to its fundamental role in cellular development, elevated levels of PRC2 have been found in cancers of the prostate, breast, lung, and blood, and pharmaceutical companies are already developing drugs to target PRC2. Wang and colleagues determined that the same mechanisms controlling PRC2 function in stem cells also applies in human cancers.

"The identification of a specific PCL in controlling PRC2 in cancer cells suggests we may be able to develop drugs targeting this PCL to regulate PRC2 function in a more controlled manner that may maintain PRC2 function in stem cells while inhibiting it in the tumor," said Wang.

This research was funded by the National Institutes of Health grants (GM085394 and GM068088), the Department of Defense, the V Foundation for Cancer Research, and the University Cancer Research Fund, and was performed in collaboration with scientists at the University of California at Riverside, Rockefeller University, Memorial Sloan-Kettering Cancer Center, and the Albert Einstein College of Medicine. Study co-authors from UNC also included Bowen Xu, a student in the Wang Lab, and Ashutosh Tripathy, a Research Professor in the Department of Biochemistry and Biophysics.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/g5nZCwhyrsQ/121227130323.htm

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Ex-President George H.W. Bush in intensive care

FILE - In a Tuesday, June 12, 2012 file photo, former President George H.W. Bush, and his wife, former first lady Barbara Bush, arrive for the premiere of HBO's new documentary on his life near the family compound in Kennebunkport, Maine. Bush spokesman Jim McGrath said Wednesday, Dec. 26. 2012 that doctors at the Houston hospital where Bush has been treated for a month remain ?cautiously optimistic? that he will recover. Still, no discharge date has been set, and McGrath says that doctors are being cautious because at Bush?s age ?sometimes issues crop up that are beyond anybody?s ability to discern or foretell.?(AP Photo/Charles Krupa, File)

FILE - In a Tuesday, June 12, 2012 file photo, former President George H.W. Bush, and his wife, former first lady Barbara Bush, arrive for the premiere of HBO's new documentary on his life near the family compound in Kennebunkport, Maine. Bush spokesman Jim McGrath said Wednesday, Dec. 26. 2012 that doctors at the Houston hospital where Bush has been treated for a month remain ?cautiously optimistic? that he will recover. Still, no discharge date has been set, and McGrath says that doctors are being cautious because at Bush?s age ?sometimes issues crop up that are beyond anybody?s ability to discern or foretell.?(AP Photo/Charles Krupa, File)

HOUSTON (AP) ? Former President George H.W. Bush is being treated in the intensive care unit at a Houston hospital after suffering "a series of setbacks," including a stubborn fever, his spokesman said.

In a brief email Wednesday, Jim McGrath, Bush's spokesman in Houston, said the 88-year-old former leader had been admitted Sunday to the ICU at Methodist Hospital. McGrath said Bush, the oldest living former U.S. president, was alert and talking to medical staff.

He said doctors are cautiously optimistic about Bush's treatment and that the former president "remains in guarded condition." He said Bush was surrounded by family.

Early Thursday, McGrath told The Associated Press he had no new information on Bush's condition and that he would release another statement "when events warrant it."

Bush has been hospitalized since Nov. 23, when he was admitted for a lingering cough related to bronchitis after having been in and out of the hospital for complications related to the illness.

A fever that kept Bush in the hospital over Christmas had gotten worse and doctors had put him on a liquids-only diet Wednesday following "a series of setbacks."

"It's an elevated fever, so it's actually gone up in the last day or two," McGrath said. "It's a stubborn fever that won't go away."

But he said the cough that initially brought Bush to the hospital had improved.

Bush was visited on Christmas by his wife, Barbara, his son, Neil, and Neil's wife, Maria, and a grandson, McGrath said. Bush's daughter, Dorothy, arrived Wednesday in Houston from Bethesda, Md. The 41st president has also been visited by his sons, George W. Bush, the 43rd president, and Jeb Bush, the former governor of Florida.

He has also been visited by former Secretary of State James A. Baker III, a longtime confidant.

Bush and his wife live in Houston during the winter and spend their summers at a home in Kennebunkport, Maine.

The former president was a naval aviator in World War II ? at one point the youngest in the Navy ? and was shot down over the Pacific. He's skydived on at least three of his birthdays since leaving the White House in 1992.

He suffers from a form of Parkinson's disease and in recent years has used a wheelchair to get around.

___

Plushnick-Masti can be followed on Twitter at https://twitter.com/RamitMastiAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-27-Bush%20Hospitalized/id-8c2dafef85764bea92a6d0df79311a81

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Russian parliament endorses anti-US adoption bill

A protester argues with police officers outside the Federation Council on Wednesday, Dec. 26, 2012. Several protesters were detained Wednesday morning outside the upper chamber of Russia's parliament as it prepared to vote on a controversial measure banning Americans from adopting Russian children. The poster held by the protester reads: ?Children get frozen in the Cold War.? (AP Photo/Alexander Zemlianichenko)

A protester argues with police officers outside the Federation Council on Wednesday, Dec. 26, 2012. Several protesters were detained Wednesday morning outside the upper chamber of Russia's parliament as it prepared to vote on a controversial measure banning Americans from adopting Russian children. The poster held by the protester reads: ?Children get frozen in the Cold War.? (AP Photo/Alexander Zemlianichenko)

Russian police officers detain a protester outside the Federation Council Wednesday, Dec. 26, 2012. Several protesters were detained Wednesday morning outside the upper chamber of Russia?s parliament which is set to vote on a measure banning Americans from adopting Russian children. (AP Photo/Alexander Zemlianichenko)

A demonstrator holds a poster reading "We are for Dima Yakovlev Bill" outside the Federation Council on Wednesday, Dec. 26, 2012. Several protesters were detained Wednesday morning outside the upper chamber of Russia's parliament as it prepared to vote on a controversial measure banning Americans from adopting Russian children. The bill is named in honor of Dima Yakovlev, a Russian toddler who was adopted by Americans and then died in 2008 after his father left him in a car in broiling heat for hours. (AP Photo/Alexander Zemlianichenko)

Russian President Vladimir Putin, left, presents a state award to famous Russian actor Konstantin Khabensky wearing a badge that reads "Children are outisde politics!" during an award ceremony in the Kremlin in Moscow, Wednesday, Dec. 26, 2012. The upper chamber of Russia's parliament on Wednesday unanimously voted in favor of a measure banning Americans from adopting Russian children. It now goes to President Vladimir Putin to sign or turn down. (AP Photo/RIA-Novosti, Alexei Nikolsky, Presidential Press Service)

(AP) ? Defying a storm of domestic and international criticism, Russia moved toward finalizing a ban on Americans adopting Russian children, as Parliament's upper house voted unanimously Wednesday in favor of a measure that President Vladimir Putin has indicated he will sign into law.

The bill is widely seen as the Kremlin's retaliation against an American law that calls for sanctions against Russians deemed to be human rights violators. It comes as Putin takes an increasingly confrontational attitude toward the West, brushing aside concerns about a crackdown on dissent and democratic freedoms.

Dozens of Russian children close to being adopted by American families now will almost certainly be blocked from leaving the country. The law also cuts off the main international adoption route for Russian children stuck in often dismal orphanages: More than 60,000 Russian youngsters have been adopted in the United States in the past 20 years. There are about 740,000 children without parental care in Russia, according to UNICEF.

All 143 members of the Federation Council present voted to support the bill, which has sparked criticism from both the United States and Russian officials, activists and artists, who say it victimizes children by depriving them of the chance to escape the squalor of orphanage life. The vote comes days after Parliament's lower house overwhelmingly approved the ban.

Seven people with posters protesting the bill were detained outside the Council before Wednesday's vote. "Children get frozen in the Cold War," one poster read. Some 60 people rallied in St. Petersburg, Russia's second largest city.

The bill is part of larger legislation by Putin-allied lawmakers retaliating against a recently signed U.S. law that calls for sanctions against Russians deemed to be human rights violators. Although Putin has not explicitly committed to signing the bill, he strongly defended it in a press conference last week as "a sufficient response" to the new U.S. law.

Originally Russia's lawmakers cobbled together a more or less a tit-for-tat response to the U.S. law, providing for travel sanctions and the seizure of financial assets in Russia of Americans determined to have violated the rights of Russians.

But it was expanded to include the adoption measure and call for a ban on any organizations that are engaged in political activities if they receive funding from U.S. citizens or are determined to be a threat to Russia's interests.

Russian children's rights ombudsman Pavel Astakhov told the Interfax news agency that 46 children who were on the verge of being adopted by Americans would stay in Russia if the bill is approved ? despite court rulings in some of these cases authorizing the adoptions.

The ombudsman supported the bill, saying that foreign adoptions discourage Russians from adopting children. "A foreigner who has paid for an adoption always gets a priority compared to potential Russian adoptive parents," Astakhov was quoted as saying. "A great country like Russia cannot sell its children."

Russian law allows foreigners to adopt only if a Russian family has not expressed interest in a child being considered for adoption.

Some top government officials, including the foreign minister, have spoken flatly against the adoption law, arguing that the measure would be in violation of Russia's constitution and international obligations.

But Senator Mikhail Margelov, chairman of the Council's foreign affairs committee, referred to the bill as "a natural and a long overdue response" to the U.S. legislation. "Children must be placed in Russian families, and this is a cornerstone issue for us," he said.

Margelov said that a bilateral Russian-U.S. agreement binds Russia to give notice of a halt to adoptions 12 months in advance. Putin spokesman Dmitry Peskov told Russian news agencies that the president would consider the bill within the next two weeks.

The measure has become one of the most debated topics in Russia.

By Tuesday, more than 100,000 Russians had signed an online petition urging the Kremlin to scrap the bill.

Over the weekend, dozens of Muscovites placed toys and lit candles in front of the Duma, Russia's lower house of parliament after it approved the bill on Friday, but security guards promptly removed them. Opposition groups said they will rally against the bill on Jan. 13, and several popular artists publicly voiced their concern about the legislation.

While receiving a state award from Putin on Wednesday, film actor Konstantin Khabensky wore a badge saying "Children Are Beyond Politics." Veteran rock musician Andrey Makarevich called on Putin Monday to stop "killing children."

During a marathon Putin press conference Thursday, eight of the 60 questions the president answered focused on the bill. Responding angrily, Putin claimed that Americans routinely mistreat children from Russia.

The bill is named in honor of Dima Yakovlev, a Russian toddler who was adopted by Americans and then died in 2008 after his father left him in a car in broiling heat for hours. The father was found not guilty of involuntary manslaughter.

Russian lawmakers argue that by banning adoptions to the U.S. they would be protecting children and encouraging adoptions inside Russia.

In a measure of the virulent anti-U.S. sentiment that has gripped parts of Russian society, a few lawmakers went even further, claiming that some Russian children were adopted by Americans only to be used for organ transplants and become sex toys or cannon fodder for the U.S. Army.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-12-26-Russia-US-Adoptions/id-20fa1ca0b93342de921e047f91b5d650

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2013 Toyota Avalon to offer Qi wireless charging

avalon-charge-1

Buyers of the 2013 Toyota Avalon can do away with car chargers and their spaghetti of wires, because the full-size sedan is the first car in the world to be made available with Qi wireless charging. The feature is included in a Technology Package which can be specified on both petrol and hybrid versions of the Avalon in Limited trim.

Qi is the global standard for wireless power and charging. Like the Chinese principle of the flow of life energy, devices are magically charged just by placing them on, or near, any Qi-enabled surface. OK, it?s not completely magic ? a fair bit of electromagnetic induction is involved.

Supplied by DENSO, the Avalon?s system utilises technology developed by ConvenientPower and Philips Lite-on Digital Solution. All the driver has to do is throw a switch to activate it, place his/her phone on the high-friction surface built into the centre console and charging begins.

avalon-charge-2

Qi wireless charging is now available for 34 mobile phone models, including the LG Google Nexus 4, Nokia Lumia 920 and HTC Windows Phone 8X.

The concept of charging without cables is not new ? in 2010,?Delphi Automotive and WiTriCity announced work on a range of?wireless charging products for EVs and Johnson Controls? ie:3 concept car featured a system similar to the one in the 2013 Avalon.

More recently, Hyundai previewed its Connectivity Concept, which does more than just charge your phone, but it?ll be some time before that makes production reality.

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Source: http://paultan.org/2012/12/26/2013-toyota-avalon-to-offer-qi-wireless-charging/

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Tuesday, December 25, 2012

Just got a new iPhone, iPad or Android device for Christmas? Gameloft cuts popular iOS and Android games to 99?

MOBILE, Alabama (Reuters) - A major winter storm system swept through the southern United States on Tuesday, spawning tornadoes in several states and killing two people in weather-related road accidents. The National Weather Service (NWS) said a tornado struck Mobile, Alabama, home to about 200,000 people, at about 5 p.m. local time (2300 GMT). There were reports of damage to trees and widespread power outages, along with some structural damage, but no injuries or fatalities. ...

Source: http://news.yahoo.com/just-got-iphone-ipad-android-device-christmas-gameloft-150009359.html

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NASA Plans To "Lasso" Asteroid and Turn It Into Space Station

People keep touting the idea of mining metals from asteroids and using it to build spacecraft outside of the earth's gravity well, but do we actually know how to do that?

The mining side of things seems relatively straight-forward (not easy, but you wouldn't need anything radically new), but smelting and refining significant amounts of ore in low gravity could be rather difficult. As far as I understand, a traditional iron smelting plant uses gravity to help with the purification, allowing the slag to float to the surface, before tapping the good quality iron from the bottom of the blast furnace.

It seems like purifying and working ore in space would require entirely new ways of working with the raw materials. Perhaps using some kind of high temperature centrifuge to spin and separate the material.

I'm not saying it's not possible, but it doesn't seem quite as easy as some of the more excitable science-fictiony plans for space exploration treat it. Many of these plans feature major problems to solve that get glossed over as minor technicalities.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/nZ20oq0BT6g/story01.htm

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